Research

Welcome to the Ucar Lab at the Jackson Laboratory!

Ucar Lab is an interdisciplinary team advancing systems immunology, single-cell genomics, and computational biology to transform our understanding of immune system aging and complex human diseases. By combining genomics and computational innovations with functional immunology, we work towards uncovering the cellular and molecular drivers behind immune aging to drive insights that have powerful implications for human health. Our ultimate goal is to reveal how aging alters immune cell transcriptional and epigenetic programs at an individual level, explore the co-factors (such as biological sex) influencing these age-related changes, and understand how these alterations impact immune responses to vaccination.

Our research centers around three transformative areas:

Diversity in Human Immune Aging & Contributing Co-Factors
We explore the individual diversity in immune aging and the role of co-factors (e.g., biological sex) that shape immune function and resilience, providing insights into personalized health strategies.

Genomic Signatures of Vaccine Responsiveness
By identifying genomic signatures associated with robust vaccine responses, we’re paving the way for precision vaccinology to enhance vaccine efficacy among older adults.

Epigenomic Signatures of Human Diseases
Our work delves into the epigenomic imprints of complex diseases and past immune responses in human cells, offering new avenues for therapeutic development.

Our vision aligns with precision medicine and precision gerontology: by understanding immune aging and disease signatures at the individual level, we aim to lead in developing interventions that could delay or even reverse age-related disorders. Leveraging these unique insights into aging, Ucar Lab is committed to opening doors to personalized, life-extending health solutions.

Explore our publications to learn more about our contributions to the field. We’re always open to connecting with passionate and talented scientists who are interested in joining us! Visit our Open Positions page to learn more about current opportunities.